Lonkkakirjaingeneraattori<\/title>\n <style>\n .genotype-container {\n display: flex;\n margin-bottom: 20px;\n }\n .genotype-select {\n flex: 1;\n margin-right: 10px;\n text-align: center;\n }\n .genotype-image {\n display: block;\n max-width: 100px;\n margin: 2px auto;\n }\n .puppy {\n display: inline-block;\n text-align: center;\n margin: 1px;\n }\n .puppyzero {\n text-align: center;\n }\n .puppy-row {\n display: flex;\n flex-wrap: wrap;\n justify-content: flex-start;\n }\n .genotype-text {\n font-weight: bold;\n margin-top: 1px;\n }\n .disease-text {\n font-size: 0.5em;\n color: #555;\n margin-top: 0;\n }\n button[type=\"submit\"] {\n position: relative; \n top: -25px;\n }\n label {\n font-weight: bold;\n }\n .lonkka-text {\n position: relative;\n display: block;\n margin: 0;\n padding: 0;\n font-weight: bold;\n }\n .disease-list {\n list-style-type: none;\n margin: 0;\n padding: 0;\n font-size: 0.9em;\n line-height: 1.2;\n }\n .disease-list li {\n padding-left: 0;\n display: inline-block;\n }\n .disease-list span {\n display: inline-block;\n }\n .puppy img {\n margin-top: 5px;\n margin-bottom: 5px;\n }\n .puppy span {\n margin-top: 0;\n margin-bottom: 2px;\n }\n <\/style>\n<\/head>\n\n<body>\n\n <form id=\"genotypeForm\">\n <div class=\"genotype-container\">\n <div class=\"genotype-select\">\n <label for=\"parent1\">Uroksen GM1-geenivirhe:<\/label>\n <select id=\"parent1\" name=\"parent1\" required>\n <option value=\"NORMAALI\/NORMAALI\">Ei ole kantaja (N\/N)<\/option>\n <option value=\"NORMAALI\/MUTAATIO\">On kantaja (N\/n)<\/option>\n <\/select>\n <img decoding=\"async\" id=\"parent1Image\" class=\"genotype-image\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg\" alt=\"Oletuskuva\">\n <div id=\"parent1Genotype\" class=\"parent-genotype\"><\/div>\n <\/div>\n\n <div class=\"genotype-select\">\n <label for=\"parent2\">Nartun GM1-geenivirhe:<\/label>\n <select id=\"parent2\" name=\"parent2\" required>\n <option value=\"NORMAALI\/NORMAALI\">Ei ole kantaja (N\/N)<\/option>\n <option value=\"NORMAALI\/MUTAATIO\">On kantaja (N\/n)<\/option>\n <\/select>\n <img decoding=\"async\" id=\"parent2Image\" class=\"genotype-image\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg\" alt=\"Oletuskuva\">\n <div id=\"parent2Genotype\" class=\"parent-genotype\"><\/div>\n <\/div>\n <\/div>\n\n <br><br>\n <button type=\"submit\">Pennuta!<\/button>\n <\/form>\n\n <div id=\"results\" class=\"puppy-container\"><\/div>\n\n <script>\n document.getElementById('parent1').addEventListener('change', function(event) {\n updateAlocusImage(event.target);\n });\n\n document.getElementById('parent2').addEventListener('change', function(event) {\n updateAlocusImage(event.target);\n });\n\n function updateAlocusImage(target) {\n var imageId = target.id + 'Image';\n var selectedValue = target.value.trim().toUpperCase();\n\n var imageUrl = getParentImageUrl(selectedValue);\n var imageElement = document.getElementById(imageId);\n\n imageElement.src = imageUrl;\n imageElement.classList.remove('hidden');\n imageElement.style.display = 'block';\n }\n\n function getParentImageUrl(genotypeValue) {\n var imageUrl = '';\n switch (genotypeValue) {\n case 'NORMAALI\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg';\n break;\n case 'NORMAALI\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/kantaja.jpg';\n break;\n case 'MUTAATIO\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/sairas.jpg';\n break;\n default:\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg';\n }\n return imageUrl;\n }\n\n document.getElementById('genotypeForm').addEventListener('submit', function(event) {\n event.preventDefault();\n\n var parent1Genotype = document.getElementById('parent1').value.trim().toUpperCase();\n var parent2Genotype = document.getElementById('parent2').value.trim().toUpperCase();\n\n var puppiesCount = calculatePuppyCount();\n\n var puppies = [];\n for (var i = 0; i < puppiesCount; i++) {\n var puppyGenotype = generateRandomPuppyGenotype(parent1Genotype, parent2Genotype);\n puppies.push(puppyGenotype);\n }\n\n var resultsHTML = '';\n if (puppiesCount === 0) {\n resultsHTML += '<div class=\"puppyzero\">';\n resultsHTML += '<img decoding=\"async\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/04\/akitapentulaatikko2.jpg\" alt=\"Kuva pentulaatikosta\"><br>';\n resultsHTML += '<\/div>';\n } else {\n resultsHTML += '<div class=\"puppy-row\">';\n puppies.forEach(function(genotype) {\n var sortedGenotype = genotype.split('\/').sort((a, b) => {\n var order = { 'NORMAALI': 1, 'MUTAATIO': 2 };\n return order[a] - order[b];\n }).join('\/');\n\n var imageData = getPuppyImageUrl(sortedGenotype);\n var imageUrl = imageData.imageUrl;\n var genotypeText = imageData.genotypeText;\n\n resultsHTML += '<div class=\"puppy\">';\n resultsHTML += '<img decoding=\"async\" src=\"' + imageUrl + '\" alt=\"Kuva pennusta\"><br>';\n resultsHTML += '<span class=\"genotype-text\">' + genotypeText + '<\/span><br>';\n resultsHTML += '<\/div>';\n });\n resultsHTML += '<\/div>';\n }\n\n document.getElementById('results').innerHTML = resultsHTML;\n });\n\n function calculatePuppyCount() {\n var randomNumber = Math.random() * 100;\n if (randomNumber < 9) { \/\/ 9% (1 pentu)\n return 1;\n } else if (randomNumber < 30) { \/\/ 21% (2 pentua)\n return 2;\n } else if (randomNumber < 68) { \/\/ 38% (3 pentua)\n return 3;\n } else if (randomNumber < 93) { \/\/ 25% (4 pentua)\n return 4;\n } else { \/\/ 7% (5 pentua)\n return 5;\n }\n}\n\n function generateRandomPuppyGenotype(parent1Genotype, parent2Genotype) {\n var possibleAlleles1 = parent1Genotype.split('\/');\n var possibleAlleles2 = parent2Genotype.split('\/');\n\n var randomIndex1 = Math.floor(Math.random() * possibleAlleles1.length);\n var randomIndex2 = Math.floor(Math.random() * possibleAlleles2.length);\n\n var allele1 = possibleAlleles1[randomIndex1];\n var allele2 = possibleAlleles2[randomIndex2];\n\n return allele1 + '\/' + allele2;\n }\n\n function getPuppyImageUrl(genotype) {\n var imageUrl = '';\n var genotypeText = '';\n\n switch (genotype) {\n case 'NORMAALI\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaapentu4.jpg';\n genotypeText = 'VAPAA';\n break;\n case 'NORMAALI\/MUTAATIO':\n case 'MUTAATIO\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/kantajapentu4.jpg';\n genotypeText = 'KANTAJA';\n break;\n case 'MUTAATIO\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/sairaspentu4.jpg';\n genotypeText = 'SAIRAS';\n break;\n default:\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/04\/kykyvarivari.jpg';\n genotypeText = 'TUNNISTAMATON';\n }\n\n return { imageUrl: imageUrl, genotypeText: genotypeText };\n }\n <\/script>\n\n<\/body>\n\n<\/html>\n\n <\/div>\r\n \n\n\n<p>Shiban GM1-gangliosidoosi on vakava aivonsurkastumasairaus, joka aiheutuu geenivirheest\u00e4. Periytymismalli on peittyv\u00e4: geenivirheen kantajat ovat terveit\u00e4, mutta kahden kantajan risteytyksess\u00e4 pentu voi peri\u00e4 viallisen geenin kummaltakin vanhemmaltaan. T\u00e4llainen pentu sairastuu gangliosidoosiin. Kantajapennut ovat kuin vanhempansa eiv\u00e4tk\u00e4 sairastu.* Geenilottokoneella voi tarkastella yksigeenist\u00e4 peittyv\u00e4sti periytyv\u00e4\u00e4 sairautta. Ja sit\u00e4 geneettist\u00e4 \"lottoa\". Jokainen pentu perii sattumanvaraisesti yhden geenimuodon kummankin vanhemman valikoimasta.<\/p>\n\n\n\n<p>Miten tehokkaasti yksi kantaja periytt\u00e4\u00e4 geenivirhett\u00e4 esimerkiksi kahteenkymmeneen pentueeseen?<\/p>\n\n\n\n<p>Risteytyskaavioissa 25 prossaa, mutta miten usein kahden kantajan pentueisiin oikeasti syntyy sairaita pentuja?<\/p>\n\n\n\n<p>Kaikki koirat ja ihmiset kantavat useita geenivirheit\u00e4. VAPAA pentu ei kanna tunnettua GM1-geenivirhett\u00e4, mutta muita tuntemattomia geenivirheit\u00e4 kyll\u00e4. <\/p>\n\n\n\n<p>Shiban GM1-geenivirheeseen on olemassa geenitesti. Testitulos voi n\u00e4ytt\u00e4\u00e4 v\u00e4h\u00e4n erilaiselta eri geenitestipalveluissa. T\u00e4ss\u00e4 on k\u00e4yt\u00f6ss\u00e4 N\/n kantajalle, mutta se voi olla my\u00f6s N\/G (UCDavis), N\/P (Genomia), N\/GM1 (Laboklin), risk variant copies 1 (WisdomPanel) jne.<\/p>\n\n\n\n<p>*Paitsi jos kohdalle osuu negatiivinen lottovoitto ja pennussa on tapahtunut uusi paha mutaatio siin\u00e4kin ehj\u00e4ss\u00e4 geeniss\u00e4.<\/p>\n\n\n\n<p>M\u00e4 en itse asiassa ole ajan tasalla GM1-geenivirheen tilanteesta. Pari vuotta sitten sairaita pentuja oli syntynyt Kiinassa ja Etel\u00e4-Koreassa, ja geenivirhe periytynyt my\u00f6s mameshibojen geenivalikoimaan. Ehk\u00e4 geenitesti on pieni investointi kun huomioidaan se, miten karmea kokemus t\u00e4m\u00e4n tyyppinen harvinainen sairaus on. <\/p>\n\n\n\n<p>Koodi ja kuvat: ChatGPT ja Craiyon AI<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shiban GM1-gangliosidoosi on vakava aivonsurkastumasairaus, joka aiheutuu geenivirheest\u00e4. Periytymismalli on peittyv\u00e4: geenivirheen kantajat ovat terveit\u00e4, mutta kahden kantajan risteytyksess\u00e4 pentu voi peri\u00e4 viallisen geenin kummaltakin vanhemmaltaan. T\u00e4llainen pentu sairastuu gangliosidoosiin. Kantajapennut ovat kuin vanhempansa eiv\u00e4tk\u00e4 sairastu.* Geenilottokoneella voi tarkastella yksigeenist\u00e4 peittyv\u00e4sti periytyv\u00e4\u00e4 sairautta. Ja sit\u00e4 geneettist\u00e4 ”lottoa”. Jokainen pentu perii sattumanvaraisesti yhden geenimuodon kummankin vanhemman […]<\/p>\n","protected":false},"author":1,"featured_media":4300,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-container-style":"default","site-container-layout":"default","site-sidebar-layout":"default","site-transparent-header":"default","disable-article-header":"default","disable-site-header":"default","disable-site-footer":"default","disable-content-area-spacing":"default","footnotes":""},"categories":[30,12],"tags":[],"class_list":["post-4261","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genetiikka","category-terveys"],"_links":{"self":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4261"}],"version-history":[{"count":33,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261\/revisions"}],"predecessor-version":[{"id":5155,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261\/revisions\/5155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/media\/4300"}],"wp:attachment":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}

\r\n \n\n\n \n \n Lonkkakirjaingeneraattori<\/title>\n <style>\n .genotype-container {\n display: flex;\n margin-bottom: 20px;\n }\n .genotype-select {\n flex: 1;\n margin-right: 10px;\n text-align: center;\n }\n .genotype-image {\n display: block;\n max-width: 100px;\n margin: 2px auto;\n }\n .puppy {\n display: inline-block;\n text-align: center;\n margin: 1px;\n }\n .puppyzero {\n text-align: center;\n }\n .puppy-row {\n display: flex;\n flex-wrap: wrap;\n justify-content: flex-start;\n }\n .genotype-text {\n font-weight: bold;\n margin-top: 1px;\n }\n .disease-text {\n font-size: 0.5em;\n color: #555;\n margin-top: 0;\n }\n button[type=\"submit\"] {\n position: relative; \n top: -25px;\n }\n label {\n font-weight: bold;\n }\n .lonkka-text {\n position: relative;\n display: block;\n margin: 0;\n padding: 0;\n font-weight: bold;\n }\n .disease-list {\n list-style-type: none;\n margin: 0;\n padding: 0;\n font-size: 0.9em;\n line-height: 1.2;\n }\n .disease-list li {\n padding-left: 0;\n display: inline-block;\n }\n .disease-list span {\n display: inline-block;\n }\n .puppy img {\n margin-top: 5px;\n margin-bottom: 5px;\n }\n .puppy span {\n margin-top: 0;\n margin-bottom: 2px;\n }\n <\/style>\n<\/head>\n\n<body>\n\n <form id=\"genotypeForm\">\n <div class=\"genotype-container\">\n <div class=\"genotype-select\">\n <label for=\"parent1\">Uroksen GM1-geenivirhe:<\/label>\n <select id=\"parent1\" name=\"parent1\" required>\n <option value=\"NORMAALI\/NORMAALI\">Ei ole kantaja (N\/N)<\/option>\n <option value=\"NORMAALI\/MUTAATIO\">On kantaja (N\/n)<\/option>\n <\/select>\n <img decoding=\"async\" id=\"parent1Image\" class=\"genotype-image\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg\" alt=\"Oletuskuva\">\n <div id=\"parent1Genotype\" class=\"parent-genotype\"><\/div>\n <\/div>\n\n <div class=\"genotype-select\">\n <label for=\"parent2\">Nartun GM1-geenivirhe:<\/label>\n <select id=\"parent2\" name=\"parent2\" required>\n <option value=\"NORMAALI\/NORMAALI\">Ei ole kantaja (N\/N)<\/option>\n <option value=\"NORMAALI\/MUTAATIO\">On kantaja (N\/n)<\/option>\n <\/select>\n <img decoding=\"async\" id=\"parent2Image\" class=\"genotype-image\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg\" alt=\"Oletuskuva\">\n <div id=\"parent2Genotype\" class=\"parent-genotype\"><\/div>\n <\/div>\n <\/div>\n\n <br><br>\n <button type=\"submit\">Pennuta!<\/button>\n <\/form>\n\n <div id=\"results\" class=\"puppy-container\"><\/div>\n\n <script>\n document.getElementById('parent1').addEventListener('change', function(event) {\n updateAlocusImage(event.target);\n });\n\n document.getElementById('parent2').addEventListener('change', function(event) {\n updateAlocusImage(event.target);\n });\n\n function updateAlocusImage(target) {\n var imageId = target.id + 'Image';\n var selectedValue = target.value.trim().toUpperCase();\n\n var imageUrl = getParentImageUrl(selectedValue);\n var imageElement = document.getElementById(imageId);\n\n imageElement.src = imageUrl;\n imageElement.classList.remove('hidden');\n imageElement.style.display = 'block';\n }\n\n function getParentImageUrl(genotypeValue) {\n var imageUrl = '';\n switch (genotypeValue) {\n case 'NORMAALI\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg';\n break;\n case 'NORMAALI\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/kantaja.jpg';\n break;\n case 'MUTAATIO\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/sairas.jpg';\n break;\n default:\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaa.jpg';\n }\n return imageUrl;\n }\n\n document.getElementById('genotypeForm').addEventListener('submit', function(event) {\n event.preventDefault();\n\n var parent1Genotype = document.getElementById('parent1').value.trim().toUpperCase();\n var parent2Genotype = document.getElementById('parent2').value.trim().toUpperCase();\n\n var puppiesCount = calculatePuppyCount();\n\n var puppies = [];\n for (var i = 0; i < puppiesCount; i++) {\n var puppyGenotype = generateRandomPuppyGenotype(parent1Genotype, parent2Genotype);\n puppies.push(puppyGenotype);\n }\n\n var resultsHTML = '';\n if (puppiesCount === 0) {\n resultsHTML += '<div class=\"puppyzero\">';\n resultsHTML += '<img decoding=\"async\" src=\"https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/04\/akitapentulaatikko2.jpg\" alt=\"Kuva pentulaatikosta\"><br>';\n resultsHTML += '<\/div>';\n } else {\n resultsHTML += '<div class=\"puppy-row\">';\n puppies.forEach(function(genotype) {\n var sortedGenotype = genotype.split('\/').sort((a, b) => {\n var order = { 'NORMAALI': 1, 'MUTAATIO': 2 };\n return order[a] - order[b];\n }).join('\/');\n\n var imageData = getPuppyImageUrl(sortedGenotype);\n var imageUrl = imageData.imageUrl;\n var genotypeText = imageData.genotypeText;\n\n resultsHTML += '<div class=\"puppy\">';\n resultsHTML += '<img decoding=\"async\" src=\"' + imageUrl + '\" alt=\"Kuva pennusta\"><br>';\n resultsHTML += '<span class=\"genotype-text\">' + genotypeText + '<\/span><br>';\n resultsHTML += '<\/div>';\n });\n resultsHTML += '<\/div>';\n }\n\n document.getElementById('results').innerHTML = resultsHTML;\n });\n\n function calculatePuppyCount() {\n var randomNumber = Math.random() * 100;\n if (randomNumber < 9) { \/\/ 9% (1 pentu)\n return 1;\n } else if (randomNumber < 30) { \/\/ 21% (2 pentua)\n return 2;\n } else if (randomNumber < 68) { \/\/ 38% (3 pentua)\n return 3;\n } else if (randomNumber < 93) { \/\/ 25% (4 pentua)\n return 4;\n } else { \/\/ 7% (5 pentua)\n return 5;\n }\n}\n\n function generateRandomPuppyGenotype(parent1Genotype, parent2Genotype) {\n var possibleAlleles1 = parent1Genotype.split('\/');\n var possibleAlleles2 = parent2Genotype.split('\/');\n\n var randomIndex1 = Math.floor(Math.random() * possibleAlleles1.length);\n var randomIndex2 = Math.floor(Math.random() * possibleAlleles2.length);\n\n var allele1 = possibleAlleles1[randomIndex1];\n var allele2 = possibleAlleles2[randomIndex2];\n\n return allele1 + '\/' + allele2;\n }\n\n function getPuppyImageUrl(genotype) {\n var imageUrl = '';\n var genotypeText = '';\n\n switch (genotype) {\n case 'NORMAALI\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/vapaapentu4.jpg';\n genotypeText = 'VAPAA';\n break;\n case 'NORMAALI\/MUTAATIO':\n case 'MUTAATIO\/NORMAALI':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/kantajapentu4.jpg';\n genotypeText = 'KANTAJA';\n break;\n case 'MUTAATIO\/MUTAATIO':\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/06\/sairaspentu4.jpg';\n genotypeText = 'SAIRAS';\n break;\n default:\n imageUrl = 'https:\/\/shibalogia.info\/wp-content\/uploads\/2024\/04\/kykyvarivari.jpg';\n genotypeText = 'TUNNISTAMATON';\n }\n\n return { imageUrl: imageUrl, genotypeText: genotypeText };\n }\n <\/script>\n\n<\/body>\n\n<\/html>\n\n <\/div>\r\n \n\n\n<p>Shiban GM1-gangliosidoosi on vakava aivonsurkastumasairaus, joka aiheutuu geenivirheest\u00e4. Periytymismalli on peittyv\u00e4: geenivirheen kantajat ovat terveit\u00e4, mutta kahden kantajan risteytyksess\u00e4 pentu voi peri\u00e4 viallisen geenin kummaltakin vanhemmaltaan. T\u00e4llainen pentu sairastuu gangliosidoosiin. Kantajapennut ovat kuin vanhempansa eiv\u00e4tk\u00e4 sairastu.* Geenilottokoneella voi tarkastella yksigeenist\u00e4 peittyv\u00e4sti periytyv\u00e4\u00e4 sairautta. Ja sit\u00e4 geneettist\u00e4 \"lottoa\". Jokainen pentu perii sattumanvaraisesti yhden geenimuodon kummankin vanhemman valikoimasta.<\/p>\n\n\n\n<p>Miten tehokkaasti yksi kantaja periytt\u00e4\u00e4 geenivirhett\u00e4 esimerkiksi kahteenkymmeneen pentueeseen?<\/p>\n\n\n\n<p>Risteytyskaavioissa 25 prossaa, mutta miten usein kahden kantajan pentueisiin oikeasti syntyy sairaita pentuja?<\/p>\n\n\n\n<p>Kaikki koirat ja ihmiset kantavat useita geenivirheit\u00e4. VAPAA pentu ei kanna tunnettua GM1-geenivirhett\u00e4, mutta muita tuntemattomia geenivirheit\u00e4 kyll\u00e4. <\/p>\n\n\n\n<p>Shiban GM1-geenivirheeseen on olemassa geenitesti. Testitulos voi n\u00e4ytt\u00e4\u00e4 v\u00e4h\u00e4n erilaiselta eri geenitestipalveluissa. T\u00e4ss\u00e4 on k\u00e4yt\u00f6ss\u00e4 N\/n kantajalle, mutta se voi olla my\u00f6s N\/G (UCDavis), N\/P (Genomia), N\/GM1 (Laboklin), risk variant copies 1 (WisdomPanel) jne.<\/p>\n\n\n\n<p>*Paitsi jos kohdalle osuu negatiivinen lottovoitto ja pennussa on tapahtunut uusi paha mutaatio siin\u00e4kin ehj\u00e4ss\u00e4 geeniss\u00e4.<\/p>\n\n\n\n<p>M\u00e4 en itse asiassa ole ajan tasalla GM1-geenivirheen tilanteesta. Pari vuotta sitten sairaita pentuja oli syntynyt Kiinassa ja Etel\u00e4-Koreassa, ja geenivirhe periytynyt my\u00f6s mameshibojen geenivalikoimaan. Ehk\u00e4 geenitesti on pieni investointi kun huomioidaan se, miten karmea kokemus t\u00e4m\u00e4n tyyppinen harvinainen sairaus on. <\/p>\n\n\n\n<p>Koodi ja kuvat: ChatGPT ja Craiyon AI<\/p>\n\n\n\n<p><\/p>\n\n\n\n<p><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Shiban GM1-gangliosidoosi on vakava aivonsurkastumasairaus, joka aiheutuu geenivirheest\u00e4. Periytymismalli on peittyv\u00e4: geenivirheen kantajat ovat terveit\u00e4, mutta kahden kantajan risteytyksess\u00e4 pentu voi peri\u00e4 viallisen geenin kummaltakin vanhemmaltaan. T\u00e4llainen pentu sairastuu gangliosidoosiin. Kantajapennut ovat kuin vanhempansa eiv\u00e4tk\u00e4 sairastu.* Geenilottokoneella voi tarkastella yksigeenist\u00e4 peittyv\u00e4sti periytyv\u00e4\u00e4 sairautta. Ja sit\u00e4 geneettist\u00e4 ”lottoa”. Jokainen pentu perii sattumanvaraisesti yhden geenimuodon kummankin vanhemman […]<\/p>\n","protected":false},"author":1,"featured_media":4300,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"site-container-style":"default","site-container-layout":"default","site-sidebar-layout":"default","site-transparent-header":"default","disable-article-header":"default","disable-site-header":"default","disable-site-footer":"default","disable-content-area-spacing":"default","footnotes":""},"categories":[30,12],"tags":[],"class_list":["post-4261","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-genetiikka","category-terveys"],"_links":{"self":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=4261"}],"version-history":[{"count":33,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261\/revisions"}],"predecessor-version":[{"id":5155,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/posts\/4261\/revisions\/5155"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=\/wp\/v2\/media\/4300"}],"wp:attachment":[{"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=4261"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=4261"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/shibalogia.info\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=4261"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}